Antonios Pouliopoulos

Associate Research Scientist

Academic Qualifications

Biography

Antonis was born in 1990 in Thessaloniki, Greece. He received his B.Sc. in Physics from Aristotle University of Thessaloniki in 2011, with a specialization in solid state physics. As an undergraduate student, he conducted research in thin film characterization using X-ray absorption spectroscopy in the University of Bologna, Italy, and the European Synchrotron Radiation facility in Grenoble, France. He earned his M.Sc. in Nanotechnology and Regenerative Medicine from University College London, United Kingdom, in 2013, where he conducted research on positron emission mammography and magnetic resonance imaging using superparamagnetic iron oxide nanoparticles as contrast agents. He obtained his Ph.D. in Bioengineering from Imperial College London, United Kingdom, in 2017, for his work on controlling microbubble dynamics in ultrasound therapy. During his Ph.D., he developed multiple techniques in the field of therapeutic ultrasound, including rapid short-pulse therapy, Doppler passive acoustic mapping, and optical methods for investigating microbubble motion during ultrasound exposure. He is currently working as an associate research scientist in the Ultrasound Elasticity Imaging Laboratory. He has received multiple awards and serves as a reviewer for more than 20 international peer-reviewed journals. He has mentored over 60 high-school, undergraduate and graduate students in their research projects and has been involved in outreach events promoting scientific research to the community. His research interests include targeted drug delivery using ultrasound, microbubble dynamics in ultrasound therapy, ultrasound therapy monitoring, and clinical translation of therapeutic ultrasound.

Awards and Prizes

Guest editor for an invited special issue in the open access journal “Pharmaceutics”.
Outstanding Reviewer 2017, 2018 and 2019 awards, Physics in Medicine and Biology, IOP (2/2018, 3/2019, and 3/2020).
Imperial College Trust postgraduate travel award (10/2016).
Best Student Poster Presentation Award. ISTU 2016, Tel Aviv, Israel (3/2016).
International Society for Therapeutic Ultrasound student travel award (3/2016)
Old Centralian’s Trust postgraduate travel award (10/2015)
Imperial College Trust postgraduate travel award (10/2015)
Imperial College London departmental studentship for PhD studies (10/2013 – 9/2016)
Bodossakis Foundation scholarship for M.Sc. studies (9/2012 – 9/2013)
Greek State Scholarships Foundation (IKY) scholarship for academic excellence during the academic year 2009-2010 (2011)
LLP/ERASMUS scholarship for student exchange period (2/2011 – 7/2011)
Greek State Scholarships Foundation (IKY) prize for the best performance among students in Physics Department during the academic year 2009-2010 (2011)

Publications

Peer-reviewed articles

Temporal Stability of Lipid-Shelled Microbubbles During Acoustically-Mediated Blood-Brain Barrier Opening

Antonios N. Pouliopoulos
Daniella A. Jimenez
Alexander Frank
Alexander Robertson
Lin Zhang
Alina R. Kline-Schoder
Vividha Bhaskar
Mitra Harpale
Elizabeth Caso
Nicholas Papapanou
Rachel Anderson
Rachel Li
Elisa E. Konofagou

A Clinical System for Non-invasive Blood–Brain Barrier Opening Using a Neuronavigation-Guided Single-Element Focused Ultrasound Transducer

Antonios N. Pouliopoulos
Shih-Ying Wu
Mark T. Burgess
Maria Eleni Karakatsani
Hermes A. S. Kamimura
Elisa E. Konofagou

Pulse inversion enhances the passive mapping of microbubble-based ultrasound therapy

Antonios N. Pouliopoulos
Mark T. Burgess
Elisa E. Konofagou

Real-time passive acoustic mapping using sparse matrix multiplication

Hermes A. S. Kamimura
Shih-Ying Wu
Julien Grondin
Robin Ji
Christian Aurup
Wenlan Zheng
Marc Heidmann
Antonios N. Pouliopoulos
Elisa E. Konofagou

Contrast-free detection of focused ultrasound-induced blood-brain barrier opening using diffusion tensor imaging

Maria Eleni Karakatsani
Antonios Pouliopoulos
Michael Liu
Sachin R Jambawalikar
Elisa E Konofagou

Focused Ultrasound-Mediated Blood-Brain Barrier Opening Increases Delivery and Efficacy of Etoposide for Glioblastoma Treatment

Hong-Jian Wei
Pavan S Upadhyayula
Antonios N Pouliopoulos
Zachary K Englander
Xu Zhang
Chia-Ing Jan
Jia Guo
Angeliki Mela
Zhiguo Zhang
Jeffrey N Bruce
Peter D Canoll
Elisa E Konofagou
Cheng-Chia Wu

Recombinant BRICHOS chaperone domains delivered to mouse brain parenchyma by focused ultrasound and microbubbles are internalized by hippocampal and cortical neurons

Lorena Galan-Acosta
Carlos Sierra
Axel Leppert
Antonios N. Pouliopoulos
Nancy Kwon
Rebecca L. Noel
Simone Tambaro
Jenny Presto
Per J. Nilsson
Elisa E. Konofagou
Jan Ove Johansson

Conference abstracts

FUSF 2020: A neuronavigation-guided clinical ultrasound system for blood-brain barrier opening at the bedside with real-time cavitation monitoring – pre-clinical evaluation in non-human primates with behavioral amelioration and immunogenicity

Antonios N. Pouliopoulos
Nancy Kwon
Greg Jensen
Anna Meaney
Yusuke Niimi
Mark T. Burgess
Robin Ji
Ji, Shih-Ying Wu
Maria Eleni Karakatsani
Alicia J. McLuckie
Fabian Munoz
Hermes A.S. Kamimura
Andrew F. Teich
Vincent P. Ferrera
Elisa E. Konofagou

FUSF 2020: Bilateral blood-brain barrier opening in mice using acoustic holograms

Sergio Jiménez-Gambín
Antonios N Pouliopoulos
Noé Jiménez
José M Benlloch
Elisa E Konofagou
Francisco Camarena

ISTU 2020: Temporal stability of therapeutic microbubbles

Antonios N. Pouliopoulos
Daniella A. Jimenez
Alexander Frank
Alexander Robertson
Lin Zhang
Alina R. Kline Schoder
Vividha Bhaskar
Mitra Harpale
Elizabeth Caso
Nicholas Papapanou
Rachel Anderson
Rachel Li
Elisa E. Konofagou

NN 2020: Stability of micron-sized cavitation nuclei within a therapeutic ultrasound field

Antonios N. Pouliopoulos
Daniella A. Jimenez
Alexander Frank
Alexander Robertson
Lin Zhang
Alina R. Kline-Schoder
Vividha Bhaskar
Mitra Harpale
Elizabeth Caso
Nicholas Papapanou
Rachel Anderson
Rachel Li
Elisa E. Konofagou

IUS 2020: Non-invasive optogenetic activation with functional ultrasound

Christian Aurup
Antonios Pouliopoulos
Stephen Lee
Elisa Konofagou

IUS 2020: First in vivo demonstration of bilateral blood-brain barrier opening using acoustic holograms in mice

Sergio Jiménez-Gambín
Antonios N. Pouliopoulos
Noé Jiménez
José M. Benlloch
Elisa E. Konofagou
Francisco Camarena

IUS 2020: Targeted Blood-Brain Barrier Opening by Focused Ultrasound Improves Spatial Memory in Wild Type Mice

Rebecca Noel
Maria Eleni Karakatsani
Maria Murillo
Alina Kline-Schoder
Robin Ji
Alec Batts
Antonios Pouliopoulos
Elisa Konofagou

IUS 2020: Temporal stability of therapeutic microbubbles

Antonios N. Pouliopoulos
Daniella A. Jimenez
Alexander Frank
Alexander Robertson
Lin Zhang
Alina R. Kline Schoder
Vividha Bhaskar
Mitra Harpale
Elizabeth Caso
Elisa E. Konofagou

FMS 2019: Modulation of decision-making behavior by deep brain focused ultrasound stimulation in nonhuman primates

Munoz F
Meaney A
Liu K
Savin-Gross A
Pouliopoulos A
Konofagou EE
Ferrera VP

ISTU 2019: A CLINICAL SYSTEM FOR NON-INVASIVE BLOOD-BRAIN BARRIER OPENING USING A NEURONAVIGATION-GUIDED SINGLE-ELEMENT TRANSDUCER

A.N. Pouliopoulos
S.W. Wu
M.T. Burgess
M.E. Karakatsani
H.A.S. Kamimura
E.E. Konofagou

ISTU 2019: TAILORING MICROBUBBLE SHELL COMPOSITION FOR THERAPEUTIC ULTRASOUND APPLICATIONS

Lin Zhang
Antonios N. Pouliopoulos
Elisa E. Konofagou

IUS 2019: Inflammatory response and cognitive function following focused ultrasound-mediated blood- brain barrier opening in non-human primates

Antonios N. Pouliopoulos
Nancy Kwon
Greg Jensen
Anna Meaney
Mark T. Burgess
Fabian Munoz Silva
Robin Ji
Vincent P. Ferrera
Elisa E. Konofagou

IUS 2018: Passive cavitation mapping during blood-brain barrier opening is facilitated by treating with ultrasonic pulses of inverse polarity

A.N. Pouliopoulos
M. Burgess
E. E. Konofagou

ISTU 2018: Focused-ultrasound-mediated delivery of virus-encoded red-shifted channelrhodopsin for fully non-invasive and remote neuronal activation in vivo

Antonios N. Poulipoulos
Nancy Kwon
Abid Hussaini
Elisa E. Konofagou

IUS 2018: Real-time displacement and cavitation imaging of non-invasive neuromodulation of the peripheral nervous system via focused ultrasound

Stephen A. Lee
Hermes A.S. Kamimura
Mark T. Burgess
Antonios Puoliopoulos
Elisa E. Konofagou

SFN 2018: Non-invasive optogenetic excitation using focused-ultrasound-mediated delivery of virus-encoded Chrimson and transcranial red-light exposure

Antonios N. Poulipoulos
Nancy Kwon
Abid Hussaini
Elisa E. Konofagou

ASA 2017: Pulse inversion therapy for improved monitoring of blood-brain barrier opening

Antonios N. Pouliopoulos
Mark T. Burgess
Elisa E. Konofagou